Alpha-GPC is highly effective at increasing plasma and brain choline levels. Choline is important for the synthesis and release of acetylcholine, a neurotransmitter involved in learning, memory, motivation, attention, and skeletal muscle contraction. Alpha-GPC appears to easily cross the blood-brain barrier and is the best absorbed form of choline for brain functional benefits. Choline is also involved in brain development and its uptake is highest during growth.