The Stress B-Vitamin complex consists of Vitamin B5, B6, B12, and folic acid. B vitamins act as cofactors in the synthesis and regulation of dopaminergic and serotonergic neurotransmitters. Both of these neurotransmitters are implicated in the regulation of mood, as well as clinical depression and anxiety. B-Vitamin supplementation has been shown to reduce stress in healthy and at-risk subjects.