Premenstra is formulated to alleviate the symptoms of premenstrual syndrome (PMS), promote hormonal harmony, and improve overall menstrual health. Premenstra's key ingredients, including myo-inositol, GABA, magnesium, vitamin B6, and more, work synergistically to address the range of physical and emotional symptoms associated with PMS. By targeting mood swings, bloating, discomfort, and hormonal imbalances, Premenstra offers a natural treatment option for patients seeking relief from PMS symptoms.
Clean Formula


Fast Fact

Calcium supplementation has been found to be effective in the reduction of psychological symptoms of premenstrual symptoms, including sadness, mood swings, and anxiety.

Fast Fact

Magnesium helps to ease the symptoms of PMS by reducing cramps and relaxing the uterus.

Fast Fact

Does myo-inositol help with PMS? Myo-inositol is a naturally occurring, nutrient-like substance that has been studied in a variety of mood and behavioural disorders. A recent study in women with pre-menstrual dysphoric disorder (PMDD) found that supplementation with 2g myo-inositol daily was able to significantly reduce symptoms.

Fast Fact

Interestingly, levels of zinc are noticeably lower in women exhibiting PMS symptoms than those who don’t. Studies have shown that supplementing zinc in the latter 2 weeks of your menstrual cycle could be enormously beneficial for PMS.

Fast Fact

Magnesium is essential for the brain’s dopaminergic synthesis. Dopamine imbalance can affect mood and can lead to overwhelming anxiety (Li 2001). Previous studies have reported decreased circulating magnesium concentrations during the luteal phase among women with PMS, suggesting that magnesium deficiency may be a key factor in the aetiology of PMS (Posaci 1994; Rosenstein 1994).

Fast Fact

Provides a woman’s body with the essential herbs and nutrients to support a healthy menstrual cycle.

Fast Fact

Premenstrual syndrome (PMS) refers to a group of physical and behavioral symptoms that occur in a cyclic pattern during the second half of the menstrual cycle.

Fast Fact

(Chasteberry) naturally helps alleviate PMS symptoms, supports healthy menstrual cycles, aids in hormone balance, and supports healthy reproductive systems.

Fast Fact

Premenstrual syndrome (PMS) affects millions of women around the world and is known as the most important disorder in women. It has been estimated that 80-90% of women experience the symptoms of PMS at reproductive age.


Vitamin B6

Pyridoxine HCL


Vitamin B-6 (pyridoxine) is important for normal brain development and for keeping the nervous system and immune system healthy.

Magnesium with Vitamin B6 is a complementary formula that plays a significant role in supporting the maintenance of good health.* Magnesium is a critical mineral needed for hundreds of essential jobs inside your body. Vitamin B6 supports nervous system health and energy metabolism.



Zinc Glycinate

Cortisol Support

Zinc plays a significant role with respect to the stress response. Prolonged stress can deplete zinc levels. Proper maintenance of zinc status can help to stabilize serum cortisol levels over time, and zinc intake has been shown to temporarily inhibit cortisol secretions. Zinc is also an essential cofactor for serotonin synthesis which positively influences mood.


Myo -Inositol

Myo -Inositol


Myo-Inositol is a metabolite present in high levels in the brain. It is important for brain cell function given its involvement in the synthesis of cell membrane phospholipids which are protective barriers for brain cells. Myo-Inositol is also an important signaling molecule which allows neurotransmitters to function. Supplementation with Myo-Inositol may support mood during stressful situations.



Gamma Amino Butyric Acid

Stress Modulator

GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. This can help with feelings of anxiety, stress, and fear.



B-Vitamin Complex

Stress Resilience

Vitamin B6  has been found to relieve a broad range of PMS symtoms including moodiness, irritability, bloating and anxiety. 

B12, like other B vitamins, is needed to make red blood cells. This is critical for replenishing blood during your period, especially if you have heavier flow.



Magnesium Chelate

Cramp Support

Magnesium helps to ease the symptoms of PMS by reducing cramps and relaxing the uterus.  According to a recent literature review, magnesium is an evidence-based treatment for PMS. Some researchers propose that it may work by calming the nervous system and by “normalizing the actions of different hormones (mainly progesterone) on the central nervous system”.  



Calcium Chelate

Serotonin Support

Calcium supplementation has been found to be effective in the reduction of psychological symptoms of premenstrual symptoms, including sadness, mood swings and anxiety.


Studies suggest that calcium deficiency during the luteal phase of the menstrual cycle can exacerbate PMS symptoms by causing depression, hallucination, and restlessness. Moreover, women who have diets rich in vitamin D and calcium are at a lower risk of developing PMS compared to other women.


In a recent study, researchers found that women with PMS who took a 500 milligram (mg) calcium supplement twice a day for three months had significantly reduced levels of fatigue, appetite changes, and depression than women who took a placebo.


NAC (N-Acetyl Cysteine)

NAC (N-Acetyl Cysteine)


NAC (N-Acetyl Cysteine): Helps the body detoxify and manage oxidative stress, potentially reducing PMS-related symptoms.



10 reviews for Premenstra

  1. Tertia

    My daughters skin has cleared up. Her moods have settled as well. Great product.

  2. Taryn (verified owner)

    So far my daughter’s acne and moods have improved drastically and she loves the taste.

  3. Louis (verified owner)

    My daughter loves the taste!

  4. Samantha (verified owner)

    My daughter has been using the product for just over two months and has experienced a marked improvement in PMS symptoms.

  5. Natalie (verified owner)

    Received positive feedback from my 15 year old daughter on day one of taking this supplement. I also noticed from my own observations that her mood and energy levels were much improved compared to typical period days. I’m very pleased with the results 👌

  6. bianca coetzer

    Long study sessions is a whole lot easier

  7. Tilana Mc Leod (verified owner)

    Such a wonderful product! I bought it for my very active daughter. Tried it myself… It made such a difference that both of us are using it now! Highly recommend 👌

  8. Elsie (verified owner)

    Great product. See results fast

  9. Elsie (verified owner)

    See results fast

  10. Nicole (verified owner)

    Great product. I can definitely see a difference in her moods. Thank you.

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PMS or premenstrual syndrome is a group of symptoms that affects up to 75% of girls and women who have regular menstrual cycles. The telltale symptoms are both physical including bloating, weight gain, breast pain, joint or muscle pain, sleep disturbances and changes in appetite as well as some psychological side effects like anger, irritability, confusion, loss of control, and difficulty in concentrating (1,2). In short, a lot of unpleasant symptoms for a teen who already has so much to deal with physically and emotionally.


The reason why some women get PMS symptoms, while others don’t isn’t currently known and although there are so many women who struggle with these symptoms every month, the research behind trying to figure out how to solve these problems is lacking (1).


At Bioteen, we decided to dig into the research that is available to create a supplement that can support your teen during this time and provide some much needed relief and this is how we created Bioteen’s Premenstra.


Let’s have a look at how Premenstra™ works:


Hormonal regulation

As the menstrual cycle is governed by hormones and an exaggerated hormonal response may be implicated in more severe PMS symptoms, it makes sense to do our best to regulate them. One of the most profound effects that hormones can have is on your teen’s emotions. Luckily there are a few nutrients that have been shown to have a calming and uplifting effect, including magnesium, calcium and myo-inositol.


Starting with magnesium, while we know that it is an essential cofactor for more than 300 biological processes, it has also been found to normalize the action that certain hormones, like progesterone, have on the central nervous system and in doing this helps to calm it down (3).


Calcium on the other hand, is involved in the production of the neurotransmitter’s serotonin (your feel good neurotransmitter) and dopamine (your reward seeking neurotransmitter) both of which are needed for mood regulation. Some research suggests that magnesium and calcium levels are often lower in women who suffer from PMS and hypothesize that correcting these deficiencies will have a knock-on effect on mood (4). In fact, other research shows that calcium supplementation is associated with up to almost a 50% reduction in PMS symptom score, especially related to mood swings, depression, tension, anxiety, anger and crying spells (5). So, it seems like calcium isn’t just needed for strong bones!


Muscle relaxation

Painful cramping is next up on the list of horrible symptoms, with some women experiencing such extreme pain that they find it difficult to continue with daily tasks. These painful cramps may happen because when the muscular outer layer of the uterus experiences hyper contractility and because of the constriction of certain blood vessels. Calcium supplementation has been shown to help with this and may reduce neuromuscular irritability and vascular reactivity (4). In addition to this, magnesium also helps to relax the smooth muscles of the uterus meaning that there is potentially less cramping and pain (3).

Foods containing natural magnesium. Mg: Chocolate, banana, cocoa, nuts, avocados, broccoli, almonds. Top view. On a white wooden background.



After ovulation there is a buildup of omega-6 fatty acids in the cell membranes. Before the period begins, progesterone levels drop and the omega 6 fatty acids are released. This release triggers a cascade of inflammatory molecules in the uterus which triggers an inflammatory response which leads to cramping as well as other systemic symptoms like period related bloating, headaches, depressed mood, irritability and reduced levels of alertness (3, 6, 7).


To help combat this inflammation we have included magnesium and vitamin B6. Magnesium helps to reduce the amount of these inflammatory molecules released (specifically one called prostaglandins) and in doing this it helps to manage cramps and pain (3) and vitamin B6 acts as an antioxidant, neutralizing the inflammatory molecules that are released. Interestingly, vitamin B6 has been shown to specifically target psychological symptoms caused by inflammation (alone and as part of a multivitamin complex) (6, 7). In addition to all this, vitamin B6 has also been shown to enhance the efficacy of both magnesium (8) and calcium (4), making it an incredibly versatile and helpful vitamin.


The bottom line

All in all, if your teen suffers from PMS symptoms there are ways that you can help. By providing sufficient doses of these effective nutrients Bioteen’s Premenstra helps to naturally target more than one pathway that results in PMS symptoms. When PMS symptoms are under control, your teen will feel better and potentially have a more positive outlook on life. This may lead to a knock-on effect on their relationships, school work and even sports performance.



  1. Csupor D, Lantos T, Hegyi P, Benkő R, Viola R, Gyöngyi Z et al. premenstrual syndrome: A meta-analysis of double-blind randomised controlled trials. Complementary Therapies in Medicine. 2019;47:102190.
  2. Shaw S, Wyatt K, Campbell J, Ernst E, Thompson-Coon J. premenstrual syndrome. Cochrane Database of Systematic Reviews. 2018;.
  3. Parazzini F, Di Martino M, Pellegrino P. Magnesium in the gynecological practice: a literature review. Magnesium Research. 2017;30(1):1-7.
  4. Taghiabadi M, Arab A, Rafie N, Askari G. Beneficial role of calcium in premenstrual syndrome: A systematic review of current literature. International Journal of Preventive Medicine. 2020;11(1):156.
  5. Thys-Jacobs S, Ceccarelli S, Bierman A, Cohen MA, Alvir J. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen InternMed 1989;4(3):183-9.
  6. Retallick-Brown H, Blampied N, Rucklidge J. A Pilot Randomized Treatment-Controlled Trial Comparing Vitamin B6 with Broad-Spectrum Micronutrients for Premenstrual Syndrome. The Journal of Alternative and Complementary Medicine. 2020;26(2):88-97.
  7. Bird R. The Emerging Role of Vitamin B6 in Inflammation and Carcinogenesis. Advances in Food and Nutrition Research. 2018:151-194.
  8. Fathizadeh N, Ebrahimi E, Valiani M, Tavakoli N, Yar MH. Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iran J Nurs Midwifery Res. 2010 Dec;15(Suppl 1):401-5.


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